Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies
Author:
Affiliation:
1. Norman Drug Discovery Training and Consulting, LLC, 8540 Bluefin Circle, Indianapolis, Indiana 46236, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00524
Reference104 articles.
1. An analysis of the attrition of drug candidates from four major pharmaceutical companies
2. Drug Safety Sciences and the Bottleneck in Drug Development
3. Drug-induced liver injury: Advances in mechanistic understanding that will inform risk management
4. Advancing Predictive Hepatotoxicity at the Intersection of Experimental, in Silico, and Artificial Intelligence Technologies
5. Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
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