Discodermolide interferes with the binding of tau protein to microtubules
Author:
Publisher
Wiley
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1016/S0014-5793(03)00181-9/fullpdf
Reference26 articles.
1. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest
2. Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,
3. A Practical Synthesis of (+)-Discodermolide and Analogues: Fragment Union by Complex Aldol Reactions
4. The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells???preliminary comparisons to paclitaxel
5. Structure of tubulin at 6.5 Å and location of the taxol-binding site
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