ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors
Author:
Publisher
Elsevier BV
Subject
Orthopedics and Sports Medicine,Biomedical Engineering,Rheumatology
Reference9 articles.
1. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro;Stanton;Nature,2005
2. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis;Glasson;Nature,2005
3. Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification;Larkin;Osteoarthritis Cartilage,2015
4. Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5;Mosyak;Protein Sci,2008
5. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization;Malfait;Osteoarthritis Cartilage,2010
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4. Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5;Osteoarthritis and Cartilage;2022-02
5. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo;International Journal of Molecular Sciences;2020-08-20
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