Affiliation:
1. Department of Biological Sciences, Mississippi State University, Box GY, Mississippi State, MS 39762, USA
Abstract
Enteric bacteria are able to resist the high concentrations of bile encountered throughout the gastrointestinal tract. Here we review the current mechanisms identified in the enteric bacteriaSalmonella,Escherichia coli,Bacillus cereusandListeria monocytogenesto resist the dangerous effects of bile. We describe the role of membrane transport systems, and their connection with DNA repair pathways, in conferring bile resistance to these enterics. We discuss the findings from recent investigations that indicate bile tolerance is dependent upon being able to resist the detergent properties of bile at both the membrane and DNA level.
Subject
Microbiology (medical),General Medicine,Microbiology
Reference66 articles.
1. Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon;Alekshun;Antimicrob Agents Chemother,1997
2. Relationship between the effects of stress induced by human bile juice and acid treatment in Vibrio cholerae;Alvarez;J Food Prot,2003
3. Bile stress response in Listeria monocytogenes LO28: adaptation, cross-protection, and identification of genetic loci involved in bile resistance;Begley;Appl Environ Microbiol,2002
4. The interaction between bacteria and bile;Begley;FEMS Microbiol Rev,2005a
5. Contribution of three bile-associated loci, bsh , pva , and btlB , to gastrointestinal persistence and bile tolerance of Listeria monocytogenes;Begley;Infect Immun,2005b
Cited by
228 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献