Affiliation:
1. Department of Biological Sciences, Mississippi State University, Box GY, Mississippi State, MS 39762, USA
Abstract
Enteric bacteria are able to resist the high concentrations of bile encountered throughout the gastrointestinal tract. Here we review the current mechanisms identified in the enteric bacteriaSalmonella,Escherichia coli,Bacillus cereusandListeria monocytogenesto resist the dangerous effects of bile. We describe the role of membrane transport systems, and their connection with DNA repair pathways, in conferring bile resistance to these enterics. We discuss the findings from recent investigations that indicate bile tolerance is dependent upon being able to resist the detergent properties of bile at both the membrane and DNA level.
Subject
Microbiology (medical),General Medicine,Microbiology
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