Aflatoxins in cereals: worldwide occurrence and dietary risk assessment

Abstract

The worldwide occurrence of aflatoxins (AFB1, AFB2, AFG1, AFG2), genotoxic mycotoxins, in raw maize, rice, sorghum and wheat samples collected since the year 2000 was evaluated using published data and occurrence data from the GEMS/Food database (https://extranet.who.int/gemsfood). Dietary risk assessments were conducted using GEMS/Food total aflatoxin occurrence and food consumption data obtained from the 17 Cluster Diets. Risk characterisation arising from aflatoxin exposure was conducted using both cancer risk and margin of exposure (MOE) approaches. A total of 89 publications were retrieved from the literature, reporting data related to 18,097 samples, of which 37.6% were positive for at least one aflatoxin. The total upper bound (UB) mean for all samples analysed was 13.6 μg/kg, and was higher for rice (24.6 μg/kg) and sorghum (25.9 μg/kg). Of data related to the analysis of 4,536 samples reported to GEMS/Food database, 12.7% were positive for at least one aflatoxin. The total UB mean was 1.9 μg/kg, and was higher for rice (2.4 μg/kg) and maize (1.6 μg/kg). Total intakes ranged from 3.0 ng/kg bw/day (Cluster C11) to 17.1 ng/kg bw/day (Cluster C09). On average, the consumption of rice contributed to 41.6% of the total aflatoxin intake in all clusters, followed by wheat (35.4%), maize (21.2%) and sorghum (1.8%). The lowest cancer risk was found in cluster C11 (0.057 cancers/year/105 individuals), and the highest in cluster C09 (0.467 cancers/year/105 individuals). MOE ranged from 56 (C11) to 10 (C09), indicating a potential risk to consumers. These results highlight the need for continuous action by health authorities to decrease aflatoxin contamination in cereals, as they are staple foods in diets worldwide. These actions include the enforcement of code of practices at the national level and the establishment of maximum contamination levels by the Codex System.