Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis-Reference-Cited by-同舟云学术

Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis

Published:2022-06 Issue:11 Volume:10 Page:
ISSN:2051-817X
Container-title:Physiological Reports
language:en
Short-container-title:Physiological Reports

Author:

Meegan Jamie E.¹^ORCID,Komalavilas Padmini²,Cheung‐Flynn Joyce²,Yim Tsz Wing²,Putz Nathan D.¹,Jesse Jordan J.¹,Smith Kyle D.¹,Sidorova Tatiana N.¹,Lee Han Noo Ri¹,Tomasek Toria¹,Shaver Ciara M.¹^ORCID,Ware Lorraine B.¹³,Brophy Colleen M.²,Bastarache Julie A.¹³⁴

Affiliation:

1. Division of Allergy, Pulmonary and Critical Care Medicine Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA

2. Division of Vascular Surgery Vanderbilt University Medical Center Nashville Tennessee USA

3. Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville Tennessee USA

4. Department of Cell and Developmental Biology Vanderbilt University Medical Center Nashville Tennessee USA

Funder

National Heart, Lung, and Blood Institute

Publisher

Wiley

Subject

Physiology (medical),Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.14814/phy2.15290

Reference36 articles.

1. P2X7 receptor antagonism ameliorates renal dysfunction in a rat model of sepsis

2. A two-hit model of sepsis plus hyperoxia causes lung permeability and inflammation

3. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice

4. Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways

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