Investigation of the effect of artemisinin administration on total oxidant/antioxidant and oxidative stress index in the liver and kidney tissue of pentylenetetrazole-induced mice

Abstract

This study was designed to investigate the changes in total oxidant (TOS)/antioxidant (TAS) and oxidative stress index (OSI) levels in liver and kidney tissues of mice pre-treatment of artemisinin against oxidative stress that may occur in mice administered pentylenetetrazole (PTZ). Swiss albino mice (Male) (n=42) were used in the study. The mice were divided into six groups and each group had seven animals (n=7): (1) Control (C) /saline Group, (2) PTZ (35 mg/kg) Group, (3) Valproate (VPA) (100 mg/kg)+PTZ Group, (4) Artemisinin (ART) (30 mg/kg)+PTZ Group, (5) ART (60 mg/kg)+PTZ Group, (6) ART (120 mg/kg)+PTZ Grubu. Mice received injections intraperitoneally (i.p.). After the treatments, the animals were observed for seizures for 30 minutes. On the last day (day 26) of the experiment, the PTZ loading dose (75 mg/kg) was administered to the mice and then the animals were sacrificed. TAS, TOS and OSI levels were measured in liver and kidney tissue. PTZ increased TOS and decreased TAS in liver and kidney tissue. ART significantly increased TAS and decreased TOS in liver tissue at increasing doses (p