Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function

Author:

Honaker Yuchi1ORCID,Hubbard Nicholas1ORCID,Xiang Yufei1ORCID,Fisher Logan1ORCID,Hagin David1ORCID,Sommer Karen1ORCID,Song Yumei1ORCID,Yang Soo Jung2ORCID,Lopez Christina1,Tappen Tori2ORCID,Dam Elizabeth M.2ORCID,Khan Iram1ORCID,Hale Malika1ORCID,Buckner Jane H.234ORCID,Scharenberg Andrew M.145ORCID,Torgerson Troy R.145ORCID,Rawlings David J.145ORCID

Affiliation:

1. Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children’s Research Institute, Seattle, WA 98101, USA.

2. Benaroya Research Institute, Seattle, WA 98101, USA.

3. Department of Medicine, University of Washington, Seattle, WA 98101, USA.

4. Department of Immunology, University of Washington, Seattle, WA 98101, USA.

5. Department of Pediatrics, University of Washington, Seattle, WA 98101, USA.

Abstract

Gene editing to insert a strong promoter upstream of endogenous FOXP3 conferred T reg -like properties and functions to primary human CD4 + T cells.

Funder

American Diabetes Association

Leona M. and Harry B. Helmsley Charitable Trust

Seattle Children’s Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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