Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis-Reference-Cited by-同舟云学术

Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis

Published:2020-02-26 Issue:532 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mack Madison R.¹²^ORCID,Brestoff Jonathan R.³^ORCID,Berrien-Elliott Melissa M.⁴^ORCID,Trier Anna M.¹²^ORCID,Yang Ting-Lin B.¹²^ORCID,McCullen Matthew³^ORCID,Collins Patrick L.³^ORCID,Niu Haixia¹²,Bodet Nancy D.¹²,Wagner Julia A.⁴,Park Eugene⁵^ORCID,Xu Amy Z.¹²⁶,Wang Fang¹²,Chibnall Rebecca²,Council M. Laurin²^ORCID,Heffington Carrie⁷,Kreisel Friederike³,Margolis David J.⁸,Sheinbein David²^ORCID,Lovato Paola⁹^ORCID,Vivier Eric¹⁰¹¹^ORCID,Cella Marina³^ORCID,Colonna Marco³^ORCID,Yokoyama Wayne M.⁵^ORCID,Oltz Eugene M.¹²,Fehniger Todd A.⁴^ORCID,Kim Brian S.¹²³^ORCID

Affiliation:

1. Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

7. Barnes-Jewish Hospital, St. Louis, MO 63110, USA.

8. Department of Dermatology and Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, Philadelphia, PA 19104, USA.

9. Skin Research, LEO Pharma A/S, Industriparken 55, Ballerup, Denmark.

10. Aix Marseille University, APHM, CNRS, INSERM, CIML, Hôpital de la Timone, Marseille-Immunopole, Marseille, France.

11. Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.

12. Department of Microbial Infection and Immunity, Ohio State University, Wexner School of Medicine, Columbus, OH 43210, USA.

Abstract

Patients with atopic dermatitis harbor deficiencies in subsets of NK cells that can be therapeutically reversed to improve disease in mice.

Funder

Howard Hughes Medical Institute

National Heart, Lung, and Blood Institute

NIH Office of the Director

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Center for Research Resources

Burroughs Wellcome Fund

National Institute of Arthritis and Musculoskeletal and Skin Diseases

H2020 European Research Council

Agence Nationale de la Recherche

MSDAVENIR

Innate Pharma

Equipe Labellisée Ligue Nationale contre le Cancer

Children’s Discovery Institute

Doris Duke Charitable Foundation

American Skin Association

LEO Pharma Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference75 articles.

1. The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions

2. Global Skin Disease Morbidity and Mortality

3. The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association

4. Th2 Cytokines and Atopic Dermatitis

5. TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

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