Genetic support for the causal association between 91 circulating inflammatory proteins and atopic dermatitis: A two‐sample Mendelian randomization trial

Author:

Du Xinran1,Shi Hongshuo2,Liu Xin1,Wang Yi1,Du Ting1,Wang Peiyao1,Cheng Linyan1,Zhu Jianyong3,Li Fulun1

Affiliation:

1. Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

2. Department of Peripheral Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China

3. Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai China

Abstract

AbstractBackgroundAtopic dermatitis (AD) is a refractory disease that occurs in clinical practice. One of the most common inflammatory skin diseases, its occurrence and development are related to inflammation. Nevertheless, the precise nature of the relationship between circulating inflammatory proteins and AD remains uncertain.MethodsA two‐sample MR analysis was performed to determine the causal relationship between the expression of 91 circulating inflammatory proteins and AD by using genome‐wide association study (GWAS) summary statistics data from the FinnGen consortia. The robustness of the MR results was assessed by means of sensitivity analysis.ResultsThe causal relationship between the expression of nine specific circulating inflammatory proteins and AD was corroborated by the inverse variance weighted (IVW) method. The findings indicated that three circulating inflammatory proteins, namely, interleukin‐18 receptor 1 [OR (CI) = 1.08 (1.05–1.11); p = 0.000001)], interleukin‐8 [OR (CI) = 1.07 (1.00–1.14); p = 0.036244)], and tumor necrosis factor ligand superfamily member 14 [OR (CI) = 1.05 (1.00–1.10); p = 0.036842)], were positively correlated with AD. Additionally, six circulating inflammatory proteins were negatively correlated with AD: the T‐cell surface glycoprotein CD5 [OR (CI) = 0.89 (0.84–0.95); p = 0.000191)], macrophage colony‐stimulating factor 1 [OR (CI) = 0.93 (0.88–0.99); p = 0.031422)], fractalkine [OR (CI) = 0.91 (0.85–0.97); p = 0.003067)], interleukin‐24 [OR (CI) = 0.91 (0.83–0.99); p = 0.031673)], signaling lymphocytic activation molecule [OR(CI) = 0.94 (0.89–1.00); p = 0.039818)], and urokinase‐type plasminogen activator [OR(CI) = 0.95 (0.90–1.00); p = 0.037037)].ConclusionThis study confirms the potential causal relationship between circulating inflammatory proteins and AD and provides guidance for the clinical diagnosis and treatment of AD.

Funder

Shanghai Municipal Health Commission

Publisher

Wiley

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