The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy

Author:

SenGupta Devi1ORCID,Brinson Cynthia2ORCID,DeJesus Edwin3,Mills Anthony4ORCID,Shalit Peter5,Guo Susan1,Cai Yanhui1,Wallin Jeffrey J.1,Zhang Liao1,Humeniuk Rita1,Begley Rebecca1,Geleziunas Romas1,Mellors John6ORCID,Wrin Terri7,Jones Norman8,Milush Jeffrey8,Ferre April L.9,Shacklett Barbara L.9ORCID,Laird Greg M.10ORCID,Moldt Brian1,Vendrame Elena1ORCID,Brainard Diana M.1,Ramgopal Moti11ORCID,Deeks Steven G.8ORCID

Affiliation:

1. Gilead Sciences Inc., Foster City, CA, USA.

2. Central Texas Clinical Research, Austin, TX, USA.

3. Orlando Immunology Center, Orlando, FL, USA.

4. Men’s Health Foundation, West Hollywood, CA, USA.

5. Peter Shalit MD and Associates, Seattle, WA, USA.

6. University of Pittsburgh, Pittsburg, PA, USA.

7. Monogram Biosciences, South San Francisco, CA, USA.

8. University of California San Francisco, San Francisco, CA, USA.

9. University of California Davis, Davis, CA, USA.

10. Accelevir Diagnostics, Baltimore, MD, USA.

11. Midway Specialty Care Center, Fort Pierce, FL, USA.

Abstract

Vesatolimod is safe and is associated with a modest delay in viral rebound in HIV controllers after ART cessation.

Funder

National Institutes of Health

Gilead Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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