Why and where an HIV cure is needed and how it might be achieved
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41586-019-1841-8.pdf
Reference131 articles.
1. Hütter, G. et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N. Engl. J. Med. 360, 692–698 (2009).
2. Gupta, R. K. et al. HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation. Nature 568, 244–248 (2019).Two HIV-infected adults 1,2 with haematological malignancies were apparently cured of HIV after an effective stem-cell transplant from an allogeneic donor whose T cells lacked CCR5, a key co-receptor for virus entry.
3. Namazi, G. et al. The control of HIV after antiretroviral medication pause (CHAMP) study: posttreatment controllers identified from 14 clinical studies. J. Infect. Dis. 218, 1954–1963 (2018).
4. Sáez-Cirión, A. et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 9, e1003211 (2013).A subset of HIV-infected adults who start ART early and remain on therapy for a sustained period are able to effectively control HIV replication after treatment interruption; although the mechanism(s) at play remain unclear, these ‘post-treatment controllers’ provide strong evidence that the host–virus association can in some settings be slanted towards ART-free viral remission.
5. Deeks, S. G. et al. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat. Med. 22, 839–850 (2016).
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