Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH-Reference-Cited by-同舟云学术

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH

Published:2017-11-08 Issue:415 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

van der Pol Atze¹^ORCID,Gil Andres²,Silljé Herman H. W.¹^ORCID,Tromp Jasper¹³,Ovchinnikova Ekaterina S.¹⁴,Vreeswijk-Baudoin Inge¹,Hoes Martijn¹,Domian Ibrahim J.⁵⁶,van de Sluis Bart⁷,van Deursen Jan M.⁸^ORCID,Voors Adriaan A.¹,van Veldhuisen Dirk J.¹,van Gilst Wiek H.¹^ORCID,Berezikov Eugene⁴^ORCID,van der Harst Pim¹^ORCID,de Boer Rudolf A.¹^ORCID,Bischoff Rainer²^ORCID,van der Meer Peter¹^ORCID

Affiliation:

1. Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.

2. Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.

3. National Heart Centre Singapore, 169609 Singapore, Singapore.

4. European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.

5. Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

6. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

7. Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.

8. Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

OPLAH is cardioprotective for myocardial infarction, and its substrate 5-oxoproline is a putative circulating marker for heart failure.

Funder

Innovational Research Incentives Scheme program of the Netherlands Organization for Scientific Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

1. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

2. Return to the fetal gene program