IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration-Reference-Cited by-同舟云学术

IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

Published:2014-04-02 Issue:230 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Doyle Sarah L.¹²,Ozaki Ema³,Brennan Kiva⁴,Humphries Marian M.³,Mulfaul Kelly¹²,Keaney James³,Kenna Paul F.³⁵,Maminishkis Arvydas⁶,Kiang Anna-Sophia³,Saunders Sean P.⁷,Hams Emily⁷,Lavelle Ed C.⁴,Gardiner Clair⁴,Fallon Padraic G.⁷,Adamson Peter⁸,Humphries Peter³,Campbell Matthew³

Affiliation:

1. Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

2. National Children’s Research Centre, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland.

3. Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.

4. School of Biochemistry and Immunology, Immunology Research Centre, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland.

5. Research Foundation, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2, Ireland.

6. National Eye Institute, National Institutes of Health, Bethesda, MD 20892–0001, USA.

7. Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

8. Ophthiris Discovery Performance Unit, GlaxoSmithKline, Stevenage SG1 2NY, UK.

Abstract

IL-18 prevents choroidal neovascularization, the hallmark pathology of wet AMD, and is not toxic to the retinal pigment epithelium.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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