The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri2079.pdf
Reference115 articles.
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2. O'Neill, L. A., Fitzgerald, K. A. & Bowie, A. G. The Toll–IL-1 receptor adaptor family grows to five members. Trends Immunol. 24, 286–290 (2003).
3. Sodergren, E. et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314, 941–952 (2006). This paper reports the striking observation that the sea urchin is predicted to contain 222 TLRs and 26 TIR-domain-containing adaptors. The reason for this diversity is as yet unclear.
4. Rast, J. P., Smith, L. C., Loza-Coll, M., Hibino, T. & Litman, G. W. Genomic insights into the immune system of the sea urchin. Science 314, 952–956 (2006).
5. Carty, M. et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nature Immunol. 7, 1074–1081 (2006). A key functional aspect of SARM is reported here — inhibition of signalling by TRIF.
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