Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy-Reference-Cited by-同舟云学术

Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

Published:2012-06-27 Issue:140 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Denmeade Samuel R.¹,Mhaka Annastasiah M.¹,Rosen D. Marc¹,Brennen W. Nathaniel¹,Dalrymple Susan¹,Dach Ingrid²,Olesen Claus²,Gurel Bora¹,DeMarzo Angelo M.¹,Wilding George³,Carducci Michael A.¹,Dionne Craig A.⁴,Møller Jesper V.²⁵,Nissen Poul²⁶,Christensen S. Brøgger⁷,Isaacs John T.¹

Affiliation:

1. The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

2. Centre for Membrane Pumps in Cells and Disease (PUMPKIN), Danish National Research Foundation, DK-8000 Aarhus, Denmark.

3. University of Wisconsin, Madison, WI 52792, USA.

4. GenSpera Inc., San Antonio, TX 78258, USA.

5. Institute of Physiology and Biophysics, Aarhus University, DK-8000 Aarhus, Denmark.

6. Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.

7. Department of Medicinal Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark.

Abstract

A prostate-specific membrane antigen–activated prodrug selectively kills cancer cells and is being tested in patients with advanced cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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