Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α-Reference-Cited by-同舟云学术

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Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α

Published:2024-02-27 Issue:4 Volume:31 Page:447-459
ISSN:1350-9047
Container-title:Cell Death & Differentiation
language:en
Short-container-title:Cell Death Differ

Author:

Chen Hu^ORCID,Yu Shuhan,Ma Ruidong,Deng Liyuan,Yi Yong^ORCID,Niu Mengmeng^ORCID,Xu Chuan^ORCID,Xiao Zhi-Xiong Jim^ORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41418-024-01271-z.pdf

Reference73 articles.

1. Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer. 2011;11:393–410.

2. Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer. 2008;8:967–75.

3. Rankin EB, Giaccia AJ. Hypoxic control of metastasis. Science. 2016;352:175–80.

4. de Heer EC, Jalving M, Harris AL. HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer. J Clin Investig. 2020;130:5074–87.

5. Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer. 2008;8:851–64.

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