Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies-Reference-Cited by-同舟云学术

Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies

Published:2024-02-06 Issue:2 Volume:16 Page:240
ISSN:1999-4923
Container-title:Pharmaceutics
language:en
Short-container-title:Pharmaceutics

Author:

Wang Yubo¹,Zhang Lu²³,Liu Chen³,Luo Yiming⁴⁵,Chen Dengyue³

Affiliation:

1. Medical College, Guangxi University, Da-Xue-Dong Road No. 100, Nanning 530004, China

2. School of Life Sciences, Xiamen University, Xiamen 361005, China

3. Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China

4. Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen 361003, China

5. The School of Clinical Medicine, Fujian Medical University, Fuzhou 351002, China

Abstract

Effective drug delivery is essential for cancer treatment. Drug delivery systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of cancer treatment. Peptides play a significant role in various biological and physiological functions and offer high design flexibility, excellent biocompatibility, adjustable morphology, and biodegradability, making them promising candidates for drug delivery. This paper reviews peptide-mediated drug delivery systems, focusing on self-assembled peptides and peptide–drug conjugates. It discusses the mechanisms and structural control of self-assembled peptides, the varieties and roles of peptide–drug conjugates, and strategies to augment peptide stability. The review concludes by addressing challenges and future directions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Fujian Province

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4923/16/2/240/pdf

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