Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention-Reference-Cited by-同舟云学术

Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention

Published:2014-10-29 Issue:260 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bergstrand Martin¹,Nosten François²³⁴,Lwin Khin Maung⁴,Karlsson Mats O.¹,White Nicholas J.²³,Tarning Joel²³

Affiliation:

1. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 751 24, Sweden.

2. Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 104 00, Thailand.

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.

4. Shoklo Malaria Research Unit (SMRU), Mae Sod 631 10, Thailand.

Abstract

An in vivo concentration-effect relationship for the malaria drug piperaquine can be used for translational simulations of expected therapeutic outcomes in vulnerable populations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference37 articles.

1. Intermittent preventive treatment against malaria: an update

2. Intermittent Presumptive Treatment for Malaria

3. Safety, efficacy and determinants of effectiveness of antimalarial drugs during pregnancy: implications for prevention programmes in Plasmodium falciparum-endemic sub-Saharan Africa

4. Antimalarial dosing regimens and drug resistance

5. Population Pharmacokinetics of Piperaquine after Two Different Treatment Regimens with Dihydroartemisinin-Piperaquine in Patients with Plasmodium falciparum Malaria in Thailand

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