Population Pharmacokinetics of Antimalarial Naphthoquine in Combination with Artemisinin in Tanzanian Children and Adults: Dose Optimization-Reference-Cited by-同舟云学术

Population Pharmacokinetics of Antimalarial Naphthoquine in Combination with Artemisinin in Tanzanian Children and Adults: Dose Optimization

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ali Ali Mohamed¹²³^ORCID,Gausi Kamunkhwala⁴,Jongo Said A.¹²³,Kassim Kamaka R.³,Mkindi Catherine¹²³,Simon Beatus³,Mtoro Ali T.³,Juma Omar A.³,Lweno Omar N.³,Gwandu Conrad H.³,Bakari Bakari M.³,Mbaga Thabiti A.³,Milando Florence A.³,Hamad Ali³,Shekalaghe Seif A.³,Abdulla Salim³,Denti Paolo⁴^ORCID,Penny Melissa A.¹²^ORCID

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Ifakara Health Institute, Bagamoyo, Tanzania

4. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

Abstract

The combination antimalarial therapy of artemisinin-naphthoquine (ART-NQ) was developed as a single-dose therapy, aiming to improve adherence relative to the multiday schedules of other artemisinin combination therapies. The pharmacokinetics of ART-NQ has not been well characterized, especially in children. A pharmacokinetic study was conducted in adults and children over 5 years of age (6 to 10, 11 to 17, and ≥18 years of age) with uncomplicated malaria in Tanzania.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01696-21

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