Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality-Reference-Cited by-同舟云学术

Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality

Published:2020-06-10 Issue:547 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Maciejewski Sonia¹^ORCID,Ruckwardt Tracy J.²^ORCID,Morabito Kaitlyn M.²^ORCID,Foreman Bryant M.¹,Burgomaster Katherine E.¹^ORCID,Gordon David N.¹,Pelc Rebecca S.¹^ORCID,DeMaso Christina R.¹,Ko Sung-Youl²^ORCID,Fisher Brian E.²,Yang Eun Sung²,Nair Deepika²,Foulds Kathryn E.²^ORCID,Todd John Paul²,Kong Wing-Pui²,Roy Vicky³^ORCID,Aleshnick Maya¹,Speer Scott D.¹^ORCID,Bourne Nigel⁴,Barrett Alan D.⁴,Nason Martha C.⁵^ORCID,Roederer Mario²^ORCID,Gaudinski Martin R.²,Chen Grace L.²^ORCID,Dowd Kimberly A.¹^ORCID,Ledgerwood Julie E.²,Alter Galit³^ORCID,Mascola John R.²^ORCID,Graham Barney S.²^ORCID,Pierson Theodore C.¹^ORCID

Affiliation:

1. Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD 20892, USA.

2. Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.

3. Ragon Institute, Cambridge, MA 02139, USA.

4. Department of Microbiology and Immunology, Department of Pathology, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.

5. Biostatistics Research Branch, Division of Clinical Research, NIAID, NIH, Bethesda, MD 20852, USA.

Abstract

Analysis of antibodies elicited by related Zika virus DNA vaccines revealed protection correlates with a capacity to neutralize mature virions.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Vaccine Research Center, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference77 articles.

1. Zika Virus Vaccine Development: Progress in the Face of New Challenges