Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

Author:

Keppeler Daniel12ORCID,Schwaerzle Michael34ORCID,Harczos Tamas15ORCID,Jablonski Lukasz15ORCID,Dieter Alexander12ORCID,Wolf Bettina15ORCID,Ayub Suleman34,Vogl Christian16ORCID,Wrobel Christian17ORCID,Hoch Gerhard15,Abdellatif Khaled15,Jeschke Marcus15ORCID,Rankovic Vladan15,Paul Oliver34ORCID,Ruther Patrick34ORCID,Moser Tobias12568ORCID

Affiliation:

1. Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany.

2. Göttingen Graduate Center for Neurosciences and Molecular Biosciences, University of Göttingen, 37075 Göttingen, Germany.

3. University of Freiburg, Department of Microsystems Engineering (IMTEK), 79110 Freiburg, Germany.

4. Cluster of Excellence BrainLinks-BrainTools, University of Freiburg, 79110 Freiburg, Germany.

5. Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.

6. Collaborative Research Center 889, University of Göttingen, 37075 Göttingen, Germany.

7. Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Göttingen, 37099 Göttingen, Germany.

8. Multiscale Bioimaging Cluster of Excellence, University Medical Center Göttingen, 37075 Göttingen, Germany.

Abstract

Optogenetic hearing restoration in rodents by LED-based multichannel optical cochlear implants provides improved spectral selectivity.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference47 articles.

1. WHO Deafness and hearing loss. World Health Organ. (2018); http://www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss.

2. Gene therapy for deafness: How close are we?

3. Gene therapy for the inner ear

4. Quo vadis, hair cell regeneration?

5. Cochlear Implants: System Design, Integration, and Evaluation

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