Gene therapy for deafness: How close are we?-Reference-Cited by-同舟云学术

Gene therapy for deafness: How close are we?

Published:2015-07-08 Issue:295 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Moser Tobias¹²³⁴⁵

Affiliation:

1. Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37099 Göttingen, Germany.

2. Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.

3. Auditory Neuroscience Group, German Primate Center, Göttingen, Germany.

4. Auditory Neuroscience Group, Max Planck Institute for Experimental Medicine, Göttingen, Germany.

5. Collaborative Research Center 889, University of Göttingen, Göttingen, Germany.

Abstract

Virus-mediated transfer of genes encoding the mechanotransducer channel candidates TMC1 and TMC2 into hair cells of the ear partially restores hearing in animal models of human genetic deafness (Askew et al ., this issue).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference10 articles.

1. Tmc gene therapy restores auditory function in deaf mice

2. Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally Mediated Gene Therapy

3. Optogenetic stimulation of the auditory pathway

4. Gene transfer into guinea pig cochlea using adeno-associated virus vectors

5. Probing the Functional Equivalence of Otoferlin and Synaptotagmin 1 in Exocytosis

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