A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery-Reference-Cited by-同舟云学术

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery

Published:2021-05-21 Issue:21 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Iwai Kenichi¹^ORCID,Nambu Tadahiro¹^ORCID,Kashima Yukie²³,Yu Jie⁴^ORCID,Eng Kurt⁴^ORCID,Miyamoto Kazumasa⁵^ORCID,Kakoi Kazuyo¹,Gotou Masamitsu⁵,Takeuchi Toshiyuki⁶,Kogame Akifumi⁶^ORCID,Sappal Jessica⁴,Murai Saomi⁷,Haeno Hiroshi²,Kageyama Shun-Ichiro³^ORCID,Kurasawa Osamu¹^ORCID,Niu Huifeng⁸^ORCID,Kannan Karuppiah⁴⁹,Ohashi Akihiro¹²⁴^ORCID

Affiliation:

1. Oncology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.

2. Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.

3. Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.

4. Oncology Drug Discovery Unit, Millennium Pharmaceuticals Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.

5. Integrated Research Laboratory, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.

6. DMPK Research Laboratories, Takeda Pharmaceutical Company Limited, Fujisawa, Japan.

7. Integrated Biology Oncology, Axcelead Drug Discovery Partners Inc., Fujisawa, Japan.

8. Oncology Translational Science, Millennium Pharmaceuticals Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.

9. Oncology Therapeutic Area Unit, Millennium Pharmaceuticals Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.

Abstract

Potential combination partners of a CDC7 inhibitor TAK-931 were identified to guide its clinical development strategy.

Funder

Takeda Science Foundation

The Grants-in-Aid for Scientific Research

The Grants-in-Aid for Fostering Joint International Research

Takeda Pharmaceutical Company, Ltd

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference45 articles.