The causes and consequences of genetic heterogeneity in cancer evolution
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature12625.pdf
Reference125 articles.
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4. Cahill, D. P., Kinzler, K. W., Vogelstein, B. & Lengauer, C. Genetic instability and Darwinian selection in tumours. Trends Biochem. Sci. 24, M57–M60 (1999). An early reference placing genomic instability within the framework of Darwinian evolution, and recognizing that there may be distinct genomic footprints for different instability mechanisms.
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