ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome

Author:

Baker Alexander T.12345ORCID,Boyd Ryan J.56ORCID,Sarkar Daipayan678ORCID,Teijeira-Crespo Alicia9,Chan Chun Kit10,Bates Emily9ORCID,Waraich Kasim11ORCID,Vant John56ORCID,Wilson Eric56ORCID,Truong Chloe D.56ORCID,Lipka-Lloyd Magdalena12ORCID,Fromme Petra56ORCID,Vermaas Josh78ORCID,Williams Dewight13ORCID,Machiesky LeeAnn14ORCID,Heurich Meike15ORCID,Nagalo Bolni M.124,Coughlan Lynda1617ORCID,Umlauf Scott14ORCID,Chiu Po-Lin56ORCID,Rizkallah Pierre J.18ORCID,Cohen Taylor S.19ORCID,Parker Alan L.9ORCID,Singharoy Abhishek56ORCID,Borad Mitesh J.1234ORCID

Affiliation:

1. Division of Hematology and Medical Oncology, Mayo Clinic, Scottsdale, AZ 85054, USA.

2. Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

3. Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.

4. Mayo Clinic Cancer Center, Phoenix, AZ 85054, USA.

5. Biodesign Center for Applied Structural Discovery, Arizona State University, Tempe, AZ 85281, USA.

6. School of Molecular Sciences, Arizona State University, Tempe, AZ 85251, USA.

7. MSU-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824.

8. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.

9. Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

10. Computational Structural Biology and Molecular Biophysics, Beckman institute, University of Illinois, IL 61801, USA.

11. Institute of Infection Immunity and Inflammation, MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.

12. Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff CF10 3AT, UK.

13. Eyring Materials Center, Arizona State University, Tempe, AZ 85281, USA.

14. Analytical Sciences, Biopharmaceutical Development, AstraZeneca, Gaithersburg, MD 20878, USA.

15. School of Pharmacy and Pharmaceutical Science, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF10 3NB, UK.

16. Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W. Baltimore Street, MD 21201, USA.

17. Center for Vaccine Development and Global Health, University of Maryland School of Medicine, 685 W. Baltimore Street, MD 21201, USA.

18. Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

19. Microbial Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.

Abstract

We observe previously unknown interactions between clinically important adenovirus vector capsids, platelet factor 4, and CAR.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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