Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue-Reference-Cited by-同舟云学术

Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue

Published:2019-10-11 Issue:40 Volume:4 Page:
ISSN:2470-9468
Container-title:Science Immunology
language:en
Short-container-title:Sci. Immunol.

Author:

Si Yu¹²^ORCID,Merz Simon F.³⁴^ORCID,Jansen Philipp⁴,Wang Baoxiao¹²,Bruderek Kirsten¹,Altenhoff Petra¹,Mattheis Stefan¹,Lang Stephan¹⁵,Gunzer Matthias³^ORCID,Klode Joachim⁴,Squire Anthony³^ORCID,Brandau Sven¹⁵^ORCID

Affiliation:

1. Department of Otorhinolaryngology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany.

2. Department of Otolaryngology, Head and Neck Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

3. Institute for Experimental Immunology and Imaging, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

4. Department of Dermatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

5. German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.

Abstract

Intratumoral physical engagement of T cells with immunosuppressive neutrophils is associated with reduced effector function.

Funder

European Cooperation in Science and Technology

China Scholarship Council

LaVision Biotec

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

Reference39 articles.

1. The Adaptive Immunologic Microenvironment in Colorectal Cancer: A Novel Perspective: Figure 1.

2. The immune contexture in human tumours: impact on clinical outcome

3. Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

4. Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

5. Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

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