Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome-Reference-Cited by-同舟云学术

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Published:2006-09-29 Issue:5795 Volume:313 Page:1960-1964
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Galon Jérôme¹²³⁴⁵,Costes Anne¹²³⁴⁵,Sanchez-Cabo Fatima¹²³⁴⁵,Kirilovsky Amos¹²³⁴⁵,Mlecnik Bernhard¹²³⁴⁵,Lagorce-Pagès Christine¹²³⁴⁵,Tosolini Marie¹²³⁴⁵,Camus Matthieu¹²³⁴⁵,Berger Anne¹²³⁴⁵,Wind Philippe¹²³⁴⁵,Zinzindohoué Franck¹²³⁴⁵,Bruneval Patrick¹²³⁴⁵,Cugnenc Paul-Henri¹²³⁴⁵,Trajanoski Zlatko¹²³⁴⁵,Fridman Wolf-Herman¹²³⁴⁵,Pagès Franck¹²³⁴⁵

Affiliation:

1. INSERM U 255, Paris, 75006 France; Université Paris-Descartes Paris 5, Faculté de Médecine, Paris, 75006 France; and Université Pierre et Marie Curie Paris 6, Institut des Cordeliers, Paris, 75006 France.

2. Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria.

3. Department of Pathology, Avicenne Hospital, Bobigny, 93017 France.

4. Department of Digestive Surgery, Avicenne Hospital, Bobigny, 93017 France.

5. Department of General and Digestive Surgery, Georges Pompidou European Hospital, AP-HP, Paris, 75015 France.

Abstract

The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. Cancer immunoediting: from immunosurveillance to tumor escape

2. The Three Es of Cancer Immunoediting

3. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

4. Reciprocal Changes in Tumor Antigenicity and Antigen-specific T Cell Function during Tumor Progression

5. Tumor Antigens Recognized by T Lymphocytes

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