Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

Author:

Galon Jérôme12345,Costes Anne12345,Sanchez-Cabo Fatima12345,Kirilovsky Amos12345,Mlecnik Bernhard12345,Lagorce-Pagès Christine12345,Tosolini Marie12345,Camus Matthieu12345,Berger Anne12345,Wind Philippe12345,Zinzindohoué Franck12345,Bruneval Patrick12345,Cugnenc Paul-Henri12345,Trajanoski Zlatko12345,Fridman Wolf-Herman12345,Pagès Franck12345

Affiliation:

1. INSERM U 255, Paris, 75006 France; Université Paris-Descartes Paris 5, Faculté de Médecine, Paris, 75006 France; and Université Pierre et Marie Curie Paris 6, Institut des Cordeliers, Paris, 75006 France.

2. Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria.

3. Department of Pathology, Avicenne Hospital, Bobigny, 93017 France.

4. Department of Digestive Surgery, Avicenne Hospital, Bobigny, 93017 France.

5. Department of General and Digestive Surgery, Georges Pompidou European Hospital, AP-HP, Paris, 75015 France.

Abstract

The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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