PDZRN3 destabilizes endothelial cell-cell junctions through a PKCζ-containing polarity complex to increase vascular permeability

Author:

Sewduth Raj N.12,Kovacic Héléna1,Jaspard-Vinassa Béatrice1,Jecko Vincent3,Wavasseur Thomas3,Fritsch Nicolas1,Pernot Mathieu14,Jeaningros Sylvie1,Roux Etienne1,Dufourcq Pascale1,Couffinhal Thierry14,Duplàa Cécile1

Affiliation:

1. Univ. Bordeaux, INSERM, UMR1034, Biology of Cardiovascular Diseases, F-33600 Pessac, France.

2. Laboratorium voor Endotheliale Moleculaire Biologie (Vesalius Research Center), 3000 Leuven, Belgium.

3. CHU de Bordeaux, Service de Neurochirurgie, F-33000 Bordeaux, France.

4. CHU de Bordeaux, Service des Maladies Cardiaques et Vasculaires, F-33600 Pessac, France.

Abstract

Inhibiting the E3 ubiquitin ligase PDZRN3 could stabilize endothelial cell connections to prevent vascular leakage.

Funder

Region Aquitaine

Fondation pour la Recherche Médicale

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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