The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies-Reference-Cited by-同舟云学术

The Basic Requirement of Tight Junction Proteins in Blood-Brain Barrier Function and Their Role in Pathologies

Published:2024-05-21 Issue:11 Volume:25 Page:5601
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Dithmer Sophie¹,Blasig Ingolf E.¹,Fraser Paul A.²,Qin Zhihai³,Haseloff Reiner F.¹

Affiliation:

1. Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany

2. Kings College London, Strand, London WC2R 2LS, UK

3. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100049, China

Abstract

This review addresses the role of tight junction proteins at the blood-brain barrier (BBB). Their expression is described, and their role in physiological and pathological processes at the BBB is discussed. Based on this, new approaches are depicted for paracellular drug delivery and diagnostics in the treatment of cerebral diseases. Recent data provide convincing evidence that, in addition to its impairment in the course of diseases, the BBB could be involved in the aetiology of CNS disorders. Further progress will be expected based on new insights in tight junction protein structure and in their involvement in signalling pathways.

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/11/5601/pdf

Reference375 articles.

1. Organization and execution of the epithelial polarity programme;Macara;Nat. Rev. Mol. Cell Biol.,2014

2. Junctional Complexes in Various Epithelia;Farquhar;J. Cell Biol.,1963

3. Roles and modes of action of nectins in cell-cell adhesion;Irie;Semin. Cell Dev. Biol.,2004

4. Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton;Hartsock;Biochim. Biophys. Acta Biomembr.,2008

5. Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling;Baum;J. Cell Biol.,2011

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