Affiliation:
1. Department of Critical Care Medicine, Union Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan China
2. Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology) Ministry of Education Wuhan China
3. Department of Neurology The First People's Hospital of Foshan Foshan China
Abstract
AbstractObjectiveTo provide thorough insight on the protective role of endothelial glucose transporter 1 (GLUT1) in ischemic stroke.MethodsWe comprehensively review the role of endothelial GLUT1 in ischemic stroke by narrating the findings concerning biological characteristics of GLUT1 in brain in depth, summarizing the changes of endothelial GLUT1 expression and activity during ischemic stroke, discussing how GLUT1 achieves its neuroprotective effect via maintaining endothelial function, and identifying some outstanding blind spots in current studies.ResultsEndothelial GLUT1 maintains persistent high glucose and energy requirements of the brain by transporting glucose through the blood–brain barrier, which preserves endothelial function and is beneficial to stroke prognosis.ConclusionThis review underscores the potential involvement of GLUT1 trafficking, activity modulation, and degradation, and we look forward to more clinical and animal studies to illuminate these mechanisms.
Funder
Basic and Applied Basic Research Foundation of Guangdong Province