Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation-Reference-Cited by-同舟云学术

Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

Published:2011-06-07 Issue:176 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Dushek Omer¹²,Aleksic Milos¹,Wheeler Richard J.¹,Zhang Hao¹,Cordoba Shaun-Paul¹,Peng Yan-Chun³,Chen Ji-Li³,Cerundolo Vincenzo³,Dong Tao³,Coombs Daniel⁴,van der Merwe Philip Anton¹

Affiliation:

1. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

2. Centre for Mathematical Biology, University of Oxford, Oxford OX1 3LB, UK.

3. Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.

4. Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada.

Abstract

Efficient T cell activation depends on the rate with which T cell receptors and antigens bind and unbind, rather than simply their equilibrium affinity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. T Cell Activation

2. Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

3. Role of the T Cell Receptor Ligand Affinity in T Cell Activation by Bacterial Superantigens

4. A Response Calculus for Immobilized T Cell Receptor Ligands

5. The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

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