Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy

Author:

McCue Amelia C.1,Demarest Stephen J.2,Froning Karen J.2,Hickey Michael J.2,Antonysamy Stephen2,Kuhlman Brian13ORCID

Affiliation:

1. Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA

2. Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA, USA

3. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA

Funder

National Institutes of Health

Publisher

Informa UK Limited

Reference43 articles.

1. T cell-engaging therapies — BiTEs and beyond

2. T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics

3. Perspective: Designing T-Cell Engagers With Better Therapeutic Windows

4. A guide to cancer immunotherapy: from T cell basic science to clinical practice

5. Full FDA Approval for Blinatumomab for ALL - NCI [Internet]. [cited 2023 Oct 2]. https://www.cancer.gov/news-events/cancer-currents-blog/2017/blinatumomab-all-fda-full-approval.

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