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Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

  • Published:2010-02 Issue:2 Volume:32 Page:163-174
  • ISSN:1074-7613
  • Container-title:Immunity
  • language:en
  • Short-container-title:Immunity

Author:

Aleksic Milos,Dushek Omer,Zhang Hao,Shenderov Eugene,Chen Ji-Li,Cerundolo Vincenzo,Coombs Daniel,van der Merwe P. Anton

Publisher

Elsevier BV

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Reference44 articles.

1. Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR;al-Ramadi;J. Immunol.,1995

2. Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens;Andersen;J. Biol. Chem.,2001

3. Structural implications for the design of molecular vaccines;Apostolopoulos;Curr. Opin. Mol. Ther.,2000

4. Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors;Baker;J. Exp. Med.,2001

5. Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor;Beddoe;Immunity,2009
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