The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands

Published:2013-07-02 Issue:282 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Anisimov Andrey¹,Leppänen Veli-Matti²,Tvorogov Denis¹,Zarkada Georgia¹²,Jeltsch Michael¹²,Holopainen Tanja¹,Kaijalainen Seppo¹,Alitalo Kari¹²

Affiliation:

1. Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.

2. Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.

Abstract

Differences in how two ligands interact with VEGFR-1 explain why only one ligand is strongly angiogenic.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. Developmental and Pathological Angiogenesis

2. Signal transduction by vascular endothelial growth factor receptors

3. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis

4. The discovery of placenta growth factor and its biological activity

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