Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells-Reference-Cited by-同舟云学术

Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells

Published:2007-07-06 Issue:5834 Volume:317 Page:130-132
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kowalski Michael P.¹²³⁴⁵,Dubouix-Bourandy Anne¹²³⁴⁵,Bajmoczi Milan¹²³⁴⁵,Golan David E.¹²³⁴⁵,Zaidi Tanweer¹²³⁴⁵,Coutinho-Sledge Yamara S.¹²³⁴⁵,Gygi Melanie P.¹²³⁴⁵,Gygi Steven P.¹²³⁴⁵,Wiemer Erik A. C.¹²³⁴⁵,Pier Gerald B.¹²³⁴⁵

Affiliation:

1. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Novartis Institute of Biomedical Research, Cambridge, MA 02139, USA.

3. Laboratoire de Bactériologie-Hygiène, Institut Fédératif de Biologie de Purpan, Toulouse, France.

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

5. Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

Abstract

The airway epithelium plays an essential role in innate immunity to lung pathogens. Ribonucleoprotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that encounter xenobiotics. However, a clear biologic function for MVP is not established. We report here that MVP is rapidly recruited to lipid rafts when human lung epithelial cells are infected with Pseudomonas aeruginosa , and maximal recruitment is dependent on bacterial binding to the cystic fibrosis transmembrane conductance regulator. MVP was also essential for optimal epithelial cell internalization and clearance of P. aeruginosa . These results suggest that MVP makes a substantial contribution to epithelial cell–mediated resistance to infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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