CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa

Published:2000-10-20 Issue:5491 Volume:290 Page:527-530
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Grassmé Heike¹,Kirschnek Susanne¹,Riethmueller Joachim¹,Riehle Andrea¹,von Kürthy Gabriele²,Lang Florian¹,Weller Michael²,Gulbins Erich¹

Affiliation:

1. Department of Physiology, University of Tuebingen, Gmelinstrasse 5, 72076 Tuebingen, Germany.

2. Department of Neurology, University of Tuebingen, Hoppe-Seyler Strasse 3, 72076 Tuebingen, Germany.

Abstract

Pseudomonas aeruginosa causes severe infections, particularly of the lung, that are life threatening. Here, we show that P. aeruginosa infection induces apoptosis of lung epithelial cells by activation of the endogenous CD95/CD95 ligand system. Deficiency of CD95 or CD95 ligand on epithelial cells prevented apoptosis of lung epithelial cells in vivo as well as in vitro. The importance of CD95/CD95 ligand–mediated lung epithelial cell apoptosis was demonstrated by the rapid development of sepsis in CD95- or CD95 ligand–deficient mice, but not in normal mice, after P. aeruginosa infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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