Induction and Evasion of Host Defenses by Type 1-Piliated Uropathogenic Escherichia coli

Author:

Mulvey Matthew A.1,Lopez-Boado Yolanda S.1,Wilson Carole L.1,Roth Robyn1,Parks William C.1,Heuser John1,Hultgren Scott J.1

Affiliation:

1. M. A. Mulvey and S. J. Hultgren, Department of Molecular Microbiology and Microbial Pathogenesis, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. Y. S. Lopez-Boado, C. L. Wilson, W. C. Parks, Department of Medicine, Box 8032, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. R. Roth and J. Heuser, Department of Cell Biology and Physiology, Box 8228, Washington University School of Medicine, 660 S. Euclid...

Abstract

Virtually all uropathogenic strains of Escherichia coli encode filamentous surface adhesive organelles called type 1 pili. High-resolution electron microscopy of infected mouse bladders revealed that type 1 pilus tips interacted directly with the lumenal surface of the bladder, which is embedded with hexagonal arrays of integral membrane glycoproteins known as uroplakins. Attached pili were shortened and facilitated intimate contact of the bacteria with the uroplakin-coated host cells. Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system. Exfoliation occurred through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation. Bacteria resisted clearance in the face of host defenses within the bladder by invading into the epithelium.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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