The Genetic Landscape of a Cell-Reference-Cited by-全球学者库

The Genetic Landscape of a Cell

Published:2010-01-22 Issue:5964 Volume:327 Page:425-431
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Costanzo Michael¹²,Baryshnikova Anastasia¹²,Bellay Jeremy³,Kim Yungil³,Spear Eric D.⁴,Sevier Carolyn S.⁴,Ding Huiming¹²,Koh Judice L.Y.¹²,Toufighi Kiana¹²,Mostafavi Sara¹⁵,Prinz Jeany¹²,St. Onge Robert P.⁶,VanderSluis Benjamin³,Makhnevych Taras⁷,Vizeacoumar Franco J.¹²,Alizadeh Solmaz¹²,Bahr Sondra¹²,Brost Renee L.¹²,Chen Yiqun¹²,Cokol Murat⁸,Deshpande Raamesh³,Li Zhijian¹²,Lin Zhen-Yuan⁹,Liang Wendy¹²,Marback Michaela¹²,Paw Jadine¹²,San Luis Bryan-Joseph¹²,Shuteriqi Ermira¹²,Tong Amy Hin Yan¹²,van Dyk Nydia¹²,Wallace Iain M.¹²¹⁰,Whitney Joseph A.¹⁵,Weirauch Matthew T.¹¹,Zhong Guoqing¹²,Zhu Hongwei¹²,Houry Walid A.⁷,Brudno Michael¹⁵,Ragibizadeh Sasan¹²,Papp Balázs¹³,Pál Csaba¹³,Roth Frederick P.⁸,Giaever Guri²¹⁰,Nislow Corey¹²,Troyanskaya Olga G.¹⁴,Bussey Howard¹⁵,Bader Gary D.¹²,Gingras Anne-Claude⁹,Morris Quaid D.¹²⁵,Kim Philip M.¹²,Kaiser Chris A.⁴,Myers Chad L.³,Andrews Brenda J.¹²,Boone Charles¹²

Affiliation:

1. Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

2. Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

3. Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.

4. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

5. Department of Computer Science, University of Toronto, Toronto, Ontario M5S 2E4, Canada.

6. Department of Biochemistry, Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.

7. Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

8. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

9. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

10. Department of Pharmacy, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

11. Department of Biomolecular Engineering, University of California, Santa Cruz, CA 95064, USA.

12. S&P Robotics, Inc., 1181 Finch Avenue West, North York, Ontario M3J 2V8, Canada.

13. Institute of Biochemistry, Biological Research Center, H-6701 Szeged, Hungary.

14. Department of Computer Science, Lewis-Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, NJ 08544, USA.

15. Biology Department, McGill University, Montreal, Quebec H3A 1B1, Canada.

Abstract

Making Connections Genetic interaction profiles highlight cross-connections between bioprocesses, providing a global view of cellular pleiotropy, and enable the prediction of genetic network hubs. Costanzo et al. (p. 425 ) performed a pairwise fitness screen covering approximately one-third of all potential genetic interactions in yeast, examining 5.4 million gene-gene pairs and generating quantitative profiles for ∼75% of the genome. Of the pairwise interactions tested, about 3% of the genes investigated interact under the conditions tested. On the basis of these data, a reference map for the yeast genetic network was created.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Systematic Mapping of Genetic Interaction Networks

2. C. H. Waddington The Strategy of the Gene (Allen & Unwin London 1957).

3. Robust Interactions

4. Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

5. Global Mapping of the Yeast Genetic Interaction Network

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