Global Mapping of the Yeast Genetic Interaction Network-Reference-Cited by-同舟云学术

Global Mapping of the Yeast Genetic Interaction Network

Published:2004-02-06 Issue:5659 Volume:303 Page:808-813
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tong Amy Hin Yan¹²³⁴⁵,Lesage Guillaume¹²³⁴⁵,Bader Gary D.¹²³⁴⁵,Ding Huiming¹²³⁴⁵,Xu Hong¹²³⁴⁵,Xin Xiaofeng¹²³⁴⁵,Young James¹²³⁴⁵,Berriz Gabriel F.¹²³⁴⁵,Brost Renee L.¹²³⁴⁵,Chang Michael¹²³⁴⁵,Chen YiQun¹²³⁴⁵,Cheng Xin¹²³⁴⁵,Chua Gordon¹²³⁴⁵,Friesen Helena¹²³⁴⁵,Goldberg Debra S.¹²³⁴⁵,Haynes Jennifer¹²³⁴⁵,Humphries Christine¹²³⁴⁵,He Grace¹²³⁴⁵,Hussein Shamiza¹²³⁴⁵,Ke Lizhu¹²³⁴⁵,Krogan Nevan¹²³⁴⁵,Li Zhijian¹²³⁴⁵,Levinson Joshua N.¹²³⁴⁵,Lu Hong¹²³⁴⁵,Ménard Patrice¹²³⁴⁵,Munyana Christella¹²³⁴⁵,Parsons Ainslie B.¹²³⁴⁵,Ryan Owen¹²³⁴⁵,Tonikian Raffi¹²³⁴⁵,Roberts Tania¹²³⁴⁵,Sdicu Anne-Marie¹²³⁴⁵,Shapiro Jesse¹²³⁴⁵,Sheikh Bilal¹²³⁴⁵,Suter Bernhard¹²³⁴⁵,Wong Sharyl L.¹²³⁴⁵,Zhang Lan V.¹²³⁴⁵,Zhu Hongwei¹²³⁴⁵,Burd Christopher G.¹²³⁴⁵,Munro Sean¹²³⁴⁵,Sander Chris¹²³⁴⁵,Rine Jasper¹²³⁴⁵,Greenblatt Jack¹²³⁴⁵,Peter Matthias¹²³⁴⁵,Bretscher Anthony¹²³⁴⁵,Bell Graham¹²³⁴⁵,Roth Frederick P.¹²³⁴⁵,Brown Grant W.¹²³⁴⁵,Andrews Brenda¹²³⁴⁵,Bussey Howard¹²³⁴⁵,Boone Charles¹²³⁴⁵

Affiliation:

1. Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5G 1L6.

2. Department of Medical Genetics and Microbiology, University of Toronto, Toronto, ON, Canada M5S 1A8.

3. Biology Department, McGill University, 1205 Dr. Penfield Avenue, Montreal, QC, Canada H3A 1B1.

4. Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, New York, NY 10021, USA.

5. Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8.

Abstract

A genetic interaction network containing ∼1000 genes and ∼4000 interactions was mapped by crossing mutations in 132 different query genes into a set of ∼4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. K. Dolinski et al. Saccharomyces Genome Database (SGD) accessed 19 August 2003. Available at www.yeastgenome.org.

2. Functional profiling of the Saccharomyces cerevisiae genome

3. Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

4. Principles for the Buffering of Genetic Variation

5. Materials and Methods are available as supporting online material on Science Online.

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