The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Author:

,Jones Robert C.,Karkanias Jim,Krasnow Mark A.,Pisco Angela Oliveira,Quake Stephen R.,Salzman Julia,Yosef Nir,Bulthaup Bryan,Brown Phillip,Harper William,Hemenez Marisa,Ponnusamy Ravikumar,Salehi Ahmad,Sanagavarapu Bhavani A.,Spallino Eileen,Aaron Ksenia A.,Concepcion Waldo,Gardner James M.,Kelly Burnett,Neidlinger Nikole,Wang Zifa,Crasta Sheela,Kolluru Saroja,Morri Maurizio,Pisco Angela Oliveira,Tan Serena Y.,Travaglini Kyle J.,Xu Chenling,Alcántara-Hernández Marcela,Almanzar Nicole,Antony Jane,Beyersdorf Benjamin,Burhan Deviana,Calcuttawala Kruti,Carter Matthew M.,Chan Charles K. F.,Chang Charles A.,Chang Stephen,Colville Alex,Crasta Sheela,Culver Rebecca N.,Cvijović Ivana,D’Amato Gaetano,Ezran Camille,Galdos Francisco X.,Gillich Astrid,Goodyer William R.,Hang Yan,Hayashi Alyssa,Houshdaran Sahar,Huang Xianxi,Irwin Juan C.,Jang SoRi,Juanico Julia Vallve,Kershner Aaron M.,Kim Soochi,Kiss Bernhard,Kolluru Saroja,Kong William,Kumar Maya E.,Kuo Angera H.,Leylek Rebecca,Li Baoxiang,Loeb Gabriel B.,Lu Wan-Jin,Mantri Sruthi,Markovic Maxim,McAlpine Patrick L.,de Morree Antoine,Morri Maurizio,Mrouj Karim,Mukherjee Shravani,Muser Tyler,Neuhöfer Patrick,Nguyen Thi D.,Perez Kimberly,Phansalkar Ragini,Pisco Angela Oliveira,Puluca Nazan,Qi Zhen,Rao Poorvi,Raquer-McKay Hayley,Schaum Nicholas,Scott Bronwyn,Seddighzadeh Bobak,Segal Joe,Sen Sushmita,Sikandar Shaheen,Spencer Sean P.,Steffes Lea C.,Subramaniam Varun R.,Swarup Aditi,Swift Michael,Travaglini Kyle J.,Van Treuren Will,Trimm Emily,Veizades Stefan,Vijayakumar Sivakamasundari,Vo Kim Chi,Vorperian Sevahn K.,Wang Wanxin,Weinstein Hannah N. W.,Winkler Juliane,Wu Timothy T. H.,Xie Jamie,Yung Andrea R.,Zhang Yue,Detweiler Angela M.,Mekonen Honey,Neff Norma F.,Sit Rene V.,Tan Michelle,Yan Jia,Bean Gregory R.,Charu Vivek,Forgó Erna,Martin Brock A.,Ozawa Michael G.,Silva Oscar,Tan Serena Y.,Toland Angus,Vemuri Venkata N. P.,Afik Shaked,Awayan Kyle,Botvinnik Olga Borisovna,Byrne Ashley,Chen Michelle,Dehghannasiri Roozbeh,Detweiler Angela M.,Gayoso Adam,Granados Alejandro A.,Li Qiqing,Mahmoudabadi Gita,McGeever Aaron,de Morree Antoine,Olivieri Julia Eve,Park Madeline,Pisco Angela Oliveira,Ravikumar Neha,Salzman Julia,Stanley Geoff,Swift Michael,Tan Michelle,Tan Weilun,Tarashansky Alexander J.,Vanheusden Rohan,Vorperian Sevahn K.,Wang Peter,Wang Sheng,Xing Galen,Xu Chenling,Yosef Nir,Alcántara-Hernández Marcela,Antony Jane,Chan Charles K. F.,Chang Charles A.,Colville Alex,Crasta Sheela,Culver Rebecca,Dethlefsen Les,Ezran Camille,Gillich Astrid,Hang Yan,Ho Po-Yi,Irwin Juan C.,Jang SoRi,Kershner Aaron M.,Kong William,Kumar Maya E.,Kuo Angera H.,Leylek Rebecca,Liu Shixuan,Loeb Gabriel B.,Lu Wan-Jin,Maltzman Jonathan S.,Metzger Ross J.,de Morree Antoine,Neuhöfer Patrick,Perez Kimberly,Phansalkar Ragini,Qi Zhen,Rao Poorvi,Raquer-McKay Hayley,Sasagawa Koki,Scott Bronwyn,Sinha Rahul,Song Hanbing,Spencer Sean P.,Swarup Aditi,Swift Michael,Travaglini Kyle J.,Trimm Emily,Veizades Stefan,Vijayakumar Sivakamasundari,Wang Bruce,Wang Wanxin,Winkler Juliane,Xie Jamie,Yung Andrea R.,Artandi Steven E.,Beachy Philip A.,Clarke Michael F.,Giudice Linda C.,Huang Franklin W.,Huang Kerwyn Casey,Idoyaga Juliana,Kim Seung K.,Krasnow Mark,Kuo Christin S.,Nguyen Patricia,Quake Stephen R.,Rando Thomas A.,Red-Horse Kristy,Reiter Jeremy,Relman David A.,Sonnenburg Justin L.,Wang Bruce,Wu Albert,Wu Sean M.,Wyss-Coray Tony

Abstract

Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type–specific RNA splicing was discovered and analyzed across tissues within an individual.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference93 articles.

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5. Single-Cell Analysis for Whole-Organism Datasets

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