Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System

Author:

Wolkow Catherine A.1,Kimura Koutarou D.2,Lee Ming-Sum1,Ruvkun Gary1

Affiliation:

1. Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.

2. Division of Biological Science, Nagoya University, Nagoya 464-8602, Japan

Abstract

An insulinlike signaling pathway controls Caenorhabditis elegans aging, metabolism, and development. Mutations in the daf-2 insulin receptor–like gene or the downstream age-1 phosphoinositide 3-kinase gene extend adult life-span by two- to threefold. To identify tissues where this pathway regulates aging and metabolism, we restored daf-2 pathway signaling to only neurons, muscle, or intestine. Insulinlike signaling in neurons alone was sufficient to specify wild-type life-span, but muscle or intestinal signaling was not. However, restoring daf-2 pathway signaling to muscle rescued metabolic defects, thus decoupling regulation of life-span and metabolism. These findings point to the nervous system as a central regulator of animal longevity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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