Global Gene Deletion Analysis Exploring Yeast Filamentous Growth-Reference-Cited by-同舟云学术

Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

Published:2012-09-14 Issue:6100 Volume:337 Page:1353-1356
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ryan Owen¹²³,Shapiro Rebecca S.²,Kurat Christoph F.¹³,Mayhew David⁴,Baryshnikova Anastasia¹²³,Chin Brian⁵,Lin Zhen-Yuan⁶,Cox Michael J.¹²³,Vizeacoumar Frederick⁶,Cheung Doris¹³,Bahr Sondra¹³,Tsui Kyle³⁷,Tebbji Faiza⁸⁹,Sellam Adnane⁸¹⁰,Istel Fabian¹¹,Schwarzmüller Tobias¹¹,Reynolds Todd B.¹²,Kuchler Karl¹¹,Gifford David K.⁵¹³,Whiteway Malcolm⁸⁹,Giaever Guri²³⁷,Nislow Corey¹²³,Costanzo Michael¹³,Gingras Anne-Claude²⁶,Mitra Robi David⁴,Andrews Brenda¹²³,Fink Gerald R.⁵¹³,Cowen Leah E.²,Boone Charles¹²³

Affiliation:

1. Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

3. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.

4. Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University, School of Medicine, St. Louis, MO 63108, USA.

5. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

6. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.

7. Department of Pharmacy, University of Toronto, Toronto, ON M5S 3E1, Canada.

8. Biotechnology Research Institute, National Research Council of Canada, Montréal, QC H4P 2R2, Canada.

9. Department of Biology, McGill University, Montréal, QC H3A 1B1, Canada.

10. Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 1B1, Canada.

11. Medical University Vienna, Christian Doppler Laboratory for Infection Biology, Max F. Perutz Laboratories, Campus Vienna Biocenter, A-1030 Vienna, Austria.

12. Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.

13. Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.

Abstract

Infectious Phenotype The pathogenic yeast Candida albicans needs to adopt a filamentous form to invade tissues. The distantly related yeast species Saccharomyces cerevisiae also takes on a filamentous form for nutrient foraging. Comparing genome-wide deletion libraries between the two species, Ryan et al. (p. 1353 ) identified genes involved in three different filamentous yeast phenotypes and found unique genes for each of these phenotypes. However, in addition, core genes, including a previously unknown conserved regulator, appear to have homologous roles in regulating filamentous growth in these distantly related yeast species.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Trimorphic stepping stones pave the way to fungal virulence

2. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast

3. Glucose depletion causes haploid invasive growth in yeast

4. Bakers' Yeast, a Model for Fungal Biofilm Formation

5. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS

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