Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward

Abstract

Battle of the Sexes In many species, males compete with one another to propagate their own DNA, often to the detriment of females (see the Perspective by Promislow and Kaeberlein ). Shi and Murphy (p. 536 , published online 19 December) discovered that mating in Caenorhabditis species causes mothers to shrink and die soon after they have ceased producing progeny. Males appear to hijack the longevity and stress resistance pathways normally employed by the mothers to slow reproduction and somatic aging in times of stress. Maures et al. (p. 541 , published online 29 November) explored why the presence of abundant mating-competent males causes a decrease in the life span of nematodes of the opposite sex and found that a secreted substance, possibly a pheromone, reproduced the effect of the males when transferred in the culture medium. Detection of pheromones from a female fruit fly is enough to cause changes in metabolism, reduce resistance to starvation, and shorten the life span of male flies. Gendron et al. (p. 544 , published online 29 November) report that the signals from the female appear to be recognized by sensory receptors on the legs of male flies.