Polymorphism of genes of renin-angiotensin-aldosterone system in the development of hypertension in workers exposed to physical factors

Abstract

Introduction. The problem of reducing the risk of cardiovascular disease among the working population today remains the most urgent. One risk factor for arterial hypertension (AH) is exposure to high levels of noise and vibration in the workplace. Along with occupational risk factors, hereditary predisposition makes a significant contribution to the development of AH. In the pathogenesis of AH, a special role is played by genes that determine the synthesis of angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin receptor type 1 (AGTR1), etc.The aim of the study was to study the polymorphism of genes of the renin-angiotensin-aldosterone system in the development of hypertension in workers exposed to physical factors (noise and vibration) in the workplace.Materials and methods. A survey of 123 men working in «Kolomna plant» (KP), 84 of them-workers who were exposed to physical factors, and 39 people who are not in contact with harmful industrial factors. Th e presence/absence of GD, the age of its beginning, blood pressure, heart rate, the total experience of work on the KP in harmful conditions were assessed on outpatient cards. Molecular genetic studies of polymorphic genes of renin-angiotensin-aldosterone system (ALU Ins/Del of ACE gene, M235T of AGT gene, a1166c of AGTR1 gene) were carried out for all examined patients.Results. The results of correlation analysis showed the presence of a significant (р<0,05) relationship between AH and noise γ=0.42 p=0.0004, total vibration γ=0.57 p=0.002, heating microclimate γ=0.57 p=0.01. The correlation between the presence of polymorphic variant M235T AGT gene and GB γ=0.35 p=0.001, as well as levels of SAD γ=0.28 p=0.00054 and dad γ=0.29 p=0.00053 in the group of workers exposed to noise was revealed. A significantly higher prevalence of the SS genotype of the AGT gene was also found in the group of workers with AH compared to carriers of the TT variant χ2=6.18 p=0.013 and all carriers (SS+ST) of the C allele compared to carriers of the allele T χ2=6.0 p=0.014. An Association between increased SAD and the presence of the ACE gene allele D (Alu Ins/Del) and the AGTR1 gene allele C (A1166C) in individuals exposed to noise and vibration in the workplace was revealed.Conclusions. The obtained results indicate the multifactorial nature of hypertension, the importance of occupational factors in the formation of AH, primarily noise and vibration, and genetic factors: homozygous variant of the CC gene AGT (Met235Th r), the presence of the d allele of the ACE gene (Alu Ins/Del) and the C allele of the AGTR1 gene (A1166C).