Single nucleotide gene polymorphisms (SNPs) as markers of the increased risk of health disorders associated with exposure to industrial noise

Abstract

It is known that the same environmental factors, including industrial ones, with the same intensity of exposure can cause different responses of the human body depending on its individual characteristics, which are determined, inter alia, by the presence and combination of single-nucleotide polymorphisms of genes responsible for the specificity of the human body's response to stress factors, which causes the importance of their study from the point of view of prevention of public health disorders. Based on the generalization and systematization of modern domestic and foreign experience, the authors have examined the use of single-nucleotide polymorphisms of genes as markers of increased risk of health disorders associated with exposure to noise in the workplace. Scientists have identified a list of specific single-nucleotide polymorphisms of genes, the presence of which can affect the development of health disorders when exposed to noise. It is shown that the use of genetic markers to assess the individual risk of health disorders of persons working under the influence of industrial noise will contribute to the development of personalized medicine and timely prevention of occupational and general diseases associated with exposure to harmful working conditions. The authors have selected for review publications devoted to studies of the body's response to industrial noise, with access to the full text.