Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera-Reference-Cited by-同舟云学术

Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera

Published:2021-01-13 Issue: Volume: Page:
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Author:

Shi Pei-Yong¹^ORCID,Xie Xuping²^ORCID,Zou Jing²,Fontes-Garfias Camila²,Xia Hongjie²,Swanson Kena³,Cutler Mark³,Cooper David³,Menachery Vineet⁴,Weaver Scott¹^ORCID,Dormitzer Philip⁵

Affiliation:

1. The University of Texas Medical Branch at Galveston

2. University of Texas Medical Branch

3. Pfizer

4. The University of Texas Medical Branch

5. Seqirus

Abstract

Abstract Rapidly spreading variants of SARS-CoV-2 that have arisen in the United Kingdom and South Africa share the spike N501Y substitution, which is of particular concern because it is located in the viral receptor binding site for cell entry and increases binding to the receptor. We generated isogenic N501 and Y501 SARS-CoV-2. Twenty human sera from the mRNA-based vaccine BNT162b2 trial exhibited equivalent neutralizing titers to the N501 and Y501 viruses.

Publisher

Research Square Platform LLC

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