Synthesis, X-ray and antimicrobial activity of isatin-3-phenylhydrazone

Author:

Konstantinovic Sandra1,Kapor Agnes2,Radovanovic Blaga3,Deak Andrea4

Affiliation:

1. Faculty of Technology, Leskovac

2. Faculty of Sciences, Department of Physics, Novi Sad

3. Faculty of Sciences, Department of Chemistry, Niš

4. Chemical Research Center, Hungarian Academy of Science, Budapest, Hungary

Abstract

Isatin-3-phenylhydrazone was synthesized and X-ray crystal structure of this compound has been solved. Its structure was also established using FTIR, UV/Vis and H-NMR spectroscopic method. The compound was tested for antimicrobial activity against Staphylococcus aureus, Bacillus subtilus, Enterococcus D, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Candida albicans. Stability of isatin-3-phenylhydrazone toward UV-A irradiation has been studied in this work. Isatin derivative undergoes bleaching following first-order kinetics.

Publisher

National Library of Serbia

Subject

General Chemical Engineering

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