Antimicrobial activity of some isatin-3-thiosemicarbazone complexes-Reference-Cited by-同舟云学术

Antimicrobial activity of some isatin-3-thiosemicarbazone complexes

Published:2008 Issue:1 Volume:73 Page:7-13
ISSN:0352-5139
Container-title:Journal of the Serbian Chemical Society
language:en
Short-container-title:JSCS

Author:

Konstantinovic Sandra¹,Radovanovic Blaga²,Sovilj Sofija³,Stanojevic Svetlana⁴

Affiliation:

1. Tehnološki fakultet, Leskovac

2. Prirodno-matematički fakultet, Odsek za hemiju, Niš

3. Hemijski fakultet, Beograd

4. zdravlja, Biohemijska laboratorija, Leskovac

Abstract

Isatin-3-thiosemicarbazone complexes with Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and Pd(II) were synthesized and evaluated for their antimicrobial activity against 7 pathogenic bacteria and 4 fungi. The complexes have an en?hanced activity compared to the ligand due to transition metal involved in coor?dination. The anti-amoebic activity in vitro was evaluated against the HM1:IMSS strain of Entamoeba histolytica and the results were compared with the standard drug, metronidazole. The preliminary test results showed that the complexes had better anti-amoebic activity than their respective ligands. Moreover, the com?plexes showed better inhibition of the test organism.

Publisher

National Library of Serbia

Subject

General Chemistry

Reference4 articles.

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3. YI-S, a Casein-free Medium for Axenic Cultivation of Entamoeba histolytica, Related Entamoeba, Giardia intestinalis and Trichomonas vaginalis

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