Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model

Author:

Caldwell Guy A.12ORCID

Affiliation:

1. The University of Alabama 1 Department of Biological Sciences , , Tuscaloosa, AL 35487 , USA

2. Center for Neurodegeneration and Experimental Therapeutics, Heersink School of Medicine, Nathan Shock Center for Research in the Basic Biology of Aging, University of Alabama at Birmingham 2 Department of Neurology , , Birmingham, AL 35294 , USA

Abstract

ABSTRACT On the 15th Anniversary of Disease Models & Mechanisms as a trailblazing venue for the dissemination of discoveries pertaining to human health involving model systems, we celebrate the journey of this journal, as mirrored through the evolution of research using the nematode roundworm, Caenorhabditis elegans. Driven by the exponential growth of genomic data, worms have advanced from a basic research tool to precise and elegant models for disease and have yielded substantive insights into numerous human disorders. A harbinger of functional genomic analysis since the inception of RNA interference screening, the directed application of C. elegans for identification of disease-modifying factors has revealed new pathways and therapeutic targets to accelerate translational outcomes. Together with advances in gene editing, worm models are now ushering in the era of precision medicine with characteristic expedience.

Publisher

The Company of Biologists

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology (miscellaneous),Medicine (miscellaneous),Neuroscience (miscellaneous)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Synergistic modelling of human disease;Disease Models & Mechanisms;2024-02-01

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